| George Stevens |
| Montgomery Clift | .... | George Eastman |
| Elizabeth Taylor | .... | Angela Vickers |
| Shelley Winters | .... | Alice Tripp |
| Anne Revere | .... | Hannah Eastman |
| Keefe Brasselle | .... | Earl Eastman |
| Fred Clark (I) | .... | Bellows |
| Raymond Burr | .... | Frank Marlowe |
| Herbert Heyes | .... | Charles Eastman |
| Shepperd Strudwick | .... | Anthony Vickers |
| Frieda Inescort | .... | Mrs. Vickers |
| Kathryn Givney | .... | Louise Eastman |
| Walter Sande | .... | Jansen |
| Ted De Corsia | .... | Judge |
| John Ridgely | .... | Coroner |
| Lois Chartrand | .... | Marsha |
| Paul Frees | .... | Morrison |
| Harry Brown | |
| Theodore Dreiser | (novel An American Tragedy) |
| Patrick Kearney | (play) |
| Michael Wilson |
| William C. Mellor |
| Daniele Amfitheatrof | (uncredited) |
| Franz Waxman | |
| Victor Young | (uncredited) |
| Edith Head |
| William Hornbeck |
| Ivan Moffat | (associate) | ||
| George Stevens Jr. |